Neuropathologic survey on TBI cases

 
   Lead Investigator:    Diego Ianco
   Institution      :    Uniformed Services University of the Health Scienc
   E-Mail           :    diego.iacono.ctr@usuhs.edu
   Proposal ID      :    714



   Proposal Description:
   The main aims for this NACC inquiring and possible future related projects are:   a) how many cases with a clinical diagnosis of dementia as well as normal         subjects had a history of trauma (of any type) across the entire NACC database.   For this part of our project we will try to analyze specific clinical,            neuropsych, etc. data to hypothesize specific TBI-related clinico-neuropsych      trajectories b) In the second arm of our project we would like to perform an      extensive neuropathologic survey (especially looking for CTE pathology) in all    dementia+TBI cases vs. dementia-non-TBI (age-matched) vs. controls. For both of   our aims any type of traumatic etiology as well as recent and remote TBI cases    will be of high value. Also, we propose to analyze cases and brains from both     NACC's modules.